The ID4 antibody - N-terminal region (ARP38058_T100) from Aviva Systems Biology is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The ID4 antibody - N-terminal region (ARP38058_T100) has been validated for the following applications: Western Blot.
Description
Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995).[supplied by OMIM]